Implantable Posterior Segment Drug Delivery Devices; Novel Alternatives to Currently Available Treatments
نویسنده
چکیده
The efficacy of drug delivery to the posterior segment by systemic, local or topical routes is hindered by the blood-retinal barrier, tight intercellular junctions and scantly vascularized spaces. Although intravitreal injection has proved effective for delivery of therapeutic agents into the vitreous cavity and retina, it is impractical for frequent or sustained dosing. Intravitreal sustained release implants offer longterm pharmacotherapeutic exposure to the posterior segment. This novel method bypasses ocular barriers, avoids systemic complications and improves compliance.
منابع مشابه
Advances in drug delivery to the posterior segment.
PURPOSE OF REVIEW Emerging developments and research for drug delivery to the posterior segment offer a promising future for the treatment of vitreoretinal disease. As new technologies enter the market, clinicians should be aware of new indications and ongoing clinical trials. RECENT FINDINGS This review summarizes the advantages and shortcomings of the most commonly used drug delivery method...
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